Randomized, Double-Blind, Placebo-Controlled Trial of Cimicifuga racemosa (Black Cohosh) in Women With Anxiety Disorder Due to Menopause

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Effect of black cohosh (cimicifuga racemosa) on vasomotor symptoms in postmenopausal women: a randomized clinical trial.

INTRODUCTION Hot flash is considered to be an early and common symptom of menopause. The present study aimed to determine the impact of black cohosh (Cimicifuga racemosa) on vasomotor symptoms in postmenopausal women. METHODS This was a randomized, double-blind, placebo-controlled clinical trial. This study was performed on 84 postmenopausal women. The participants were randomly divided into ...

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Isolation of CYP3A4 Inhibitors from the Black Cohosh (Cimicifuga racemosa)

Recent investigation on drug interaction has shown that some foods and herbal medicines increase the oral availability of a variety of CYP3A4 substrates, which is caused by the reduction of CYP3A4 in intestinal epithelium. During the course of our investigation on CYP3A4 interaction, we found that the commercially available dietary supplement made from black cohosh (Cimicifuga racemosa) showed ...

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Muscle damage induced by black cohosh (Cimicifuga racemosa).

Extracts of black cohosh (Cimicifuga racemosa) are commonly used for the treatment of symptoms associated with menopause. Adverse events with black cohosh are rare, mild and reversible. A few number of serious adverse events, including hepatic and circulatory conditions, have been also reported, but without a clear causality relationship. We report the case of a woman with severe asthenia and v...

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A Randomized, Double-Blind, Placebo-Controlled Trial

Results: The cumulative number of gadoliniumenhancing MRI lesions during the first 6 months were similar in the -3 fatty acids and placebo groups (median difference, 1; 95% CI, 0 to 3; P=.09). No difference in relapse rate was detected after 6 (median difference, 0; 95% CI, 0 to 0; P=.54) or 24 (median difference, 0; 95% CI, 0 to 0; P=.72) months. The proportion of patients without disability p...

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ژورنال

عنوان ژورنال: Journal of Clinical Psychopharmacology

سال: 2009

ISSN: 0271-0749

DOI: 10.1097/jcp.0b013e3181b2abf2